This whole cholesterol guideline shift has been a long time coming.  An admission that the numbers don't add up is really that.  Linus Pauling and colleagues suggested decades ago that LDL was a substitute for low antioxidants and that was the actual MOA of Statins benefit.
So many examples of where the pharmaceutical industry FDA marriage has got it wrong: Atenolol turned out to be BID after decades of QD dosing.  More...